1 00:00:00,260 --> 00:00:10,320 [Music] 2 00:00:15,940 --> 00:00:12,970 it's gonna have to give you guys an 3 00:00:20,170 --> 00:00:15,950 introduction to biology and the greater 4 00:00:22,300 --> 00:00:20,180 context of astrobiology so we can think 5 00:00:24,880 --> 00:00:22,310 about the ball the biologists 6 00:00:26,470 --> 00:00:24,890 contribution or their utility to 7 00:00:28,270 --> 00:00:26,480 astrobiology and I think this is a 8 00:00:31,600 --> 00:00:28,280 really interesting question because I 9 00:00:32,950 --> 00:00:31,610 really don't think that the full 10 00:00:35,290 --> 00:00:32,960 potential of the biologists have been 11 00:00:36,610 --> 00:00:35,300 realized yet and that's really for sort 12 00:00:37,840 --> 00:00:36,620 of the plain reason that we haven't 13 00:00:39,489 --> 00:00:37,850 really found anything yet 14 00:00:42,459 --> 00:00:39,499 so we haven't found any of these guides 15 00:00:43,930 --> 00:00:42,469 or something like this we haven't really 16 00:00:45,309 --> 00:00:43,940 found any life-forms Ector 17 00:00:46,689 --> 00:00:45,319 extraterrestrial life-forms that the 18 00:00:50,229 --> 00:00:46,699 biologists could then go in and CAD or 19 00:00:52,599 --> 00:00:50,239 categorize and characterize but they can 20 00:00:54,610 --> 00:00:52,609 still do some some things so one of the 21 00:00:56,169 --> 00:00:54,620 things biologists can do in the context 22 00:00:58,180 --> 00:00:56,179 of astrobiology is look at the origin of 23 00:01:00,340 --> 00:00:58,190 life on Earth and what that informs us 24 00:01:03,520 --> 00:01:00,350 about the origin of life elsewhere 25 00:01:05,229 --> 00:01:03,530 so obviously the origin of all life way 26 00:01:07,570 --> 00:01:05,239 back seems to tell your life but also 27 00:01:10,510 --> 00:01:07,580 evolution throughout time so eukaryotic 28 00:01:12,190 --> 00:01:10,520 life multicellularity large macro fauna 29 00:01:15,580 --> 00:01:12,200 and then even the evolution of things 30 00:01:16,780 --> 00:01:15,590 like intelligence in biology and so a 31 00:01:19,210 --> 00:01:16,790 few of the talks we're gonna give today 32 00:01:20,530 --> 00:01:19,220 are gonna cover that topic most of them 33 00:01:22,810 --> 00:01:20,540 are gonna center around here at the 34 00:01:25,990 --> 00:01:22,820 beginning but valerio is gonna tell us 35 00:01:30,570 --> 00:01:26,000 about the evolution of biopolymers and 36 00:01:33,460 --> 00:01:30,580 so molecules important to biology mostly 37 00:01:35,050 --> 00:01:33,470 exist as as palmer's so things like DNA 38 00:01:37,540 --> 00:01:35,060 and protein so the strung together 39 00:01:38,680 --> 00:01:37,550 change of monomers but what's 40 00:01:41,500 --> 00:01:38,690 interesting is that a lot of the 41 00:01:43,860 --> 00:01:41,510 monomers that make up present-day 42 00:01:47,560 --> 00:01:43,870 biopolymers are sort of really hard to 43 00:01:50,200 --> 00:01:47,570 assemble under prebiotic conditions and 44 00:01:51,850 --> 00:01:50,210 so a lot of people think that the 45 00:01:53,860 --> 00:01:51,860 monomers that we know and love today are 46 00:01:56,620 --> 00:01:53,870 actually descended from sort of these 47 00:01:59,520 --> 00:01:56,630 these proto monomers that made up proto 48 00:02:02,470 --> 00:01:59,530 polymers of similar but but 49 00:02:05,410 --> 00:02:02,480 fundamentally different molecules the 50 00:02:06,790 --> 00:02:05,420 layers can tell us about that Jose is 51 00:02:08,139 --> 00:02:06,800 then gonna tell us about the origin of 52 00:02:09,940 --> 00:02:08,149 viruses and so this is a really 53 00:02:11,020 --> 00:02:09,950 interesting topic because I don't think 54 00:02:15,490 --> 00:02:11,030 it's one a lot of people think of 55 00:02:17,410 --> 00:02:15,500 everyone so obsessed with with finding 56 00:02:18,880 --> 00:02:17,420 the origin about cellular life where as 57 00:02:21,190 --> 00:02:18,890 you know we have these viruses 58 00:02:23,050 --> 00:02:21,200 that have a huge bearing on curbing 59 00:02:24,640 --> 00:02:23,060 biological populations down from 60 00:02:27,910 --> 00:02:24,650 single-cell bacteria all the way up to 61 00:02:30,220 --> 00:02:27,920 the humans these things that are 62 00:02:34,090 --> 00:02:30,230 technically nonliving a cellular life 63 00:02:36,490 --> 00:02:34,100 forms who have genomes that not only DNA 64 00:02:38,500 --> 00:02:36,500 like all cellular life but also RNA and 65 00:02:40,600 --> 00:02:38,510 so trying to pinpoint how these how 66 00:02:44,110 --> 00:02:40,610 these things evolved why they evolved is 67 00:02:48,930 --> 00:02:44,120 very interesting question in terms of 68 00:02:52,979 --> 00:02:51,790 finally under the umbrella of this topic 69 00:02:56,170 --> 00:02:52,989 Anna's going to talk to us about 70 00:02:59,170 --> 00:02:56,180 membrane membrane formation and this is 71 00:03:02,020 --> 00:02:59,180 a really important step in terms of 72 00:03:06,009 --> 00:03:02,030 going from prebiotic chemistry to 73 00:03:07,360 --> 00:03:06,019 cellular life because sort of we can 74 00:03:08,979 --> 00:03:07,370 think of without a membrane we sort of 75 00:03:10,630 --> 00:03:08,989 have this diffuse prebiotic chemistry 76 00:03:13,259 --> 00:03:10,640 where things are far apart they're not 77 00:03:16,870 --> 00:03:13,269 high concentration molecules that are 78 00:03:18,880 --> 00:03:16,880 reacting with each with each other might 79 00:03:21,190 --> 00:03:18,890 not be doing so in a very fast fashion 80 00:03:23,160 --> 00:03:21,200 but then if you can enclose this in a 81 00:03:25,000 --> 00:03:23,170 membrane you're concentrating and 82 00:03:27,460 --> 00:03:25,010 compartmentalizing these molecules so 83 00:03:29,410 --> 00:03:27,470 that they can have they can interact a 84 00:03:30,840 --> 00:03:29,420 lot more commonly and a lot faster with 85 00:03:33,069 --> 00:03:30,850 each other so you're sort of 86 00:03:35,979 --> 00:03:33,079 exponentially than increasing from that 87 00:03:37,840 --> 00:03:35,989 point getting to sort of something we 88 00:03:42,460 --> 00:03:37,850 would we would recognize as a modern 89 00:03:45,460 --> 00:03:42,470 life point so or just like another thing 90 00:03:48,819 --> 00:03:45,470 biologists can do is extra charge 91 00:03:51,100 --> 00:03:48,829 through analog studies and so right here 92 00:03:52,750 --> 00:03:51,110 is just the earth and obviously we can 93 00:03:54,699 --> 00:03:52,760 think of this as environment their 94 00:03:57,370 --> 00:03:54,709 environments on earth that are analogs 95 00:03:59,350 --> 00:03:57,380 for other planets either in our solar 96 00:04:01,630 --> 00:03:59,360 system or even exoplanets things like 97 00:04:03,310 --> 00:04:01,640 that because of the geochemical that the 98 00:04:06,940 --> 00:04:03,320 atmospheric conditions in these 99 00:04:09,310 --> 00:04:06,950 environments they mimic us you know with 100 00:04:11,530 --> 00:04:09,320 something like your OPA or Mars this can 101 00:04:12,940 --> 00:04:11,540 also apply to organisms themselves so 102 00:04:15,699 --> 00:04:12,950 you can have an organism that because 103 00:04:18,520 --> 00:04:15,709 because of the metabolism metabolism it 104 00:04:19,630 --> 00:04:18,530 employs it is an analogue it might not 105 00:04:21,940 --> 00:04:19,640 necessarily live in an analog 106 00:04:24,850 --> 00:04:21,950 environment but it could be an analog 107 00:04:26,350 --> 00:04:24,860 for an organism we might see on another 108 00:04:29,080 --> 00:04:26,360 environment for instance perchlorate 109 00:04:31,540 --> 00:04:29,090 reducers might not all live in Mars 110 00:04:32,350 --> 00:04:31,550 analog environments but that might be a 111 00:04:33,820 --> 00:04:32,360 very interesting 112 00:04:37,659 --> 00:04:33,830 metabolism for something that would be 113 00:04:38,890 --> 00:04:37,669 living on Mars right now so Laura's 114 00:04:41,860 --> 00:04:38,900 gonna talk to us about analog 115 00:04:44,170 --> 00:04:41,870 environments and she's gonna she's gonna 116 00:04:46,929 --> 00:04:44,180 talk about the the Atacama Desert in the 117 00:04:48,730 --> 00:04:46,939 Andes and you can just see basically you 118 00:04:51,249 --> 00:04:48,740 know the picture you know this is Earth 119 00:04:53,020 --> 00:04:51,259 Mars obviously but you know very similar 120 00:04:54,700 --> 00:04:53,030 and so what we do in these analog 121 00:04:55,749 --> 00:04:54,710 environments is basically go in and we 122 00:04:57,969 --> 00:04:55,759 look at who's there and what they're 123 00:04:58,719 --> 00:04:57,979 doing so we look first look at who's 124 00:05:01,149 --> 00:04:58,729 there 125 00:05:04,629 --> 00:05:01,159 and then probably more importantly how 126 00:05:06,790 --> 00:05:04,639 are they making their living there how 127 00:05:09,550 --> 00:05:06,800 are they utilizing what's there to to to 128 00:05:14,529 --> 00:05:09,560 grow to make to make necessary molecules 129 00:05:16,570 --> 00:05:14,539 and divide so those two and then another 130 00:05:18,550 --> 00:05:16,580 one that maybe even as thought of but 131 00:05:20,950 --> 00:05:18,560 that Larry do Lucas really introduced 132 00:05:23,110 --> 00:05:20,960 very well is that the biological effects 133 00:05:25,330 --> 00:05:23,120 of spaceflight in the space like our 134 00:05:27,850 --> 00:05:25,340 space environment so something like in a 135 00:05:30,339 --> 00:05:27,860 microgravity environment how that 136 00:05:33,129 --> 00:05:30,349 affects organisms all the way up from 137 00:05:33,909 --> 00:05:33,139 humans down to down to bacteria and so 138 00:05:36,510 --> 00:05:33,919 that's a really interesting question 139 00:05:39,850 --> 00:05:36,520 because this is an environment that 140 00:05:42,329 --> 00:05:39,860 nature and evolution have never seen and 141 00:05:45,010 --> 00:05:42,339 have never had to plank plan for so so 142 00:05:46,119 --> 00:05:45,020 understanding you know how how it adapts 143 00:05:49,149 --> 00:05:46,129 to this environment or what changes 144 00:05:52,420 --> 00:05:49,159 happen a very interesting question 145 00:05:55,659 --> 00:05:52,430 so Michaels gonna talk to us about that 146 00:05:58,930 --> 00:05:55,669 with this model gram positive bacteria 147 00:06:00,760 --> 00:05:58,940 organism called bacillus subtlest and 148 00:06:02,860 --> 00:06:00,770 he's basically just gonna look at gene 149 00:06:05,170 --> 00:06:02,870 expression comparing that to you know 150 00:06:07,719 --> 00:06:05,180 let's say you know we have a cell with 151 00:06:09,790 --> 00:06:07,729 where gene Y is turned on and gene Z is 152 00:06:11,499 --> 00:06:09,800 is turned off on earth but then we put 153 00:06:13,749 --> 00:06:11,509 it up in the international space system 154 00:06:15,279 --> 00:06:13,759 and then under all conditions being the 155 00:06:18,100 --> 00:06:15,289 same except for the fact that it's now 156 00:06:20,379 --> 00:06:18,110 in space well gy is turned off and gene 157 00:06:25,689 --> 00:06:20,389 Z is now turned on and so so what why 158 00:06:27,070 --> 00:06:25,699 does that happen so then finally it sort 159 00:06:29,050 --> 00:06:27,080 of goes along with this third goal point 160 00:06:32,260 --> 00:06:29,060 we have planetary protection human 161 00:06:33,999 --> 00:06:32,270 colonization of planetary bodies so 162 00:06:35,499 --> 00:06:34,009 there's a reason NASA spent all this 163 00:06:37,170 --> 00:06:35,509 money to make these things that they're 164 00:06:39,399 --> 00:06:37,180 sending out into the out into space 165 00:06:41,800 --> 00:06:39,409 extremely sterile extremely abiotic 166 00:06:44,110 --> 00:06:41,810 that's because we're very worried about 167 00:06:45,240 --> 00:06:44,120 bringing things like microorganisms from 168 00:06:46,950 --> 00:06:45,250 Earth and landing 169 00:06:49,350 --> 00:06:46,960 on an environment March where they might 170 00:06:50,750 --> 00:06:49,360 be able to grow and and now we have 171 00:06:54,900 --> 00:06:50,760 basically compromised 172 00:06:57,380 --> 00:06:54,910 the planet by bringing earth earthbound 173 00:07:00,390 --> 00:06:57,390 bacteria to that and so there's a lot of 174 00:07:01,950 --> 00:07:00,400 research looking at how basically we can 175 00:07:05,940 --> 00:07:01,960 keep from messing up the planet but all 176 00:07:07,830 --> 00:07:05,950 then also how we can while trying to not 177 00:07:11,340 --> 00:07:07,840 do that you know form settlements or 178 00:07:13,740 --> 00:07:11,350 stable colonies on these planets both 179 00:07:16,160 --> 00:07:13,750 sort of self-contained ones on places 180 00:07:18,720 --> 00:07:16,170 like the Moon or Mars and then also 181 00:07:20,700 --> 00:07:18,730 possibly on planets that have might have 182 00:07:25,100 --> 00:07:20,710 atmospheres that are conducive to human 183 00:07:28,200 --> 00:07:25,110 life open settlements and I don't think 184 00:07:30,510 --> 00:07:28,210 we're gonna make it today for this talk 185 00:07:32,280 --> 00:07:30,520 but she was going to give this really 186 00:07:35,550 --> 00:07:32,290 interesting talk about basically looking 187 00:07:36,810 --> 00:07:35,560 at how people aren't humans on earth 188 00:07:38,850 --> 00:07:36,820 through time have affected their 189 00:07:40,260 --> 00:07:38,860 environment both closed systems natural 190 00:07:42,420 --> 00:07:40,270 systems that aren't affected aren't as 191 00:07:44,190 --> 00:07:42,430 affected by humans and then other open 192 00:07:46,260 --> 00:07:44,200 systems and really what that means for 193 00:07:49,310 --> 00:07:46,270 our ability to basically sustain 194 00:07:52,140 --> 00:07:49,320 something like a some type of dome on 195 00:07:54,990 --> 00:07:52,150 colony on earth or on the Moon or Mars 196 00:07:57,450 --> 00:07:55,000 but also some type of actual new 197 00:07:58,980 --> 00:07:57,460 settlement uncontained settlement on an 198 00:08:01,890 --> 00:07:58,990 exoplanet that might have a an 199 00:08:07,290 --> 00:08:01,900 atmosphere an eco sphere similar to 200 00:08:09,030 --> 00:08:07,300 Earth so with that I just like to invite 201 00:08:10,680 --> 00:08:09,040 you to sit back relax and enjoy what I'm 202 00:08:15,110 --> 00:08:10,690 sure will be some fascinating and very